The world has begun a slow crawl out of the upheaval of COVID-19, but the psychological sequelae will be prevalent for years to come. Understanding how stress works in the brain and body—and how we can facilitate resilience and recovery—will be the key to preventing a full-blown mental health crisis on a global scale. Mount Sinai has been on the forefront of trauma, stress, depression, and resilience research for decades. This virtual symposium covers the latest: what we know, and what we are learning that can equip us in addressing the pandemic’s psychological repercussions.