Craig Katz, MD, breaks down how to deliver psychological first aid in a disaster setting in order to prevent post-disaster psychopathology—most commonly major depression, PTSD, and alcohol abuse. He discusses the core tenets of National Center for PTSD and National Child Traumatic Stress Network’s Psychological First Aid Field Operations Guide: initial contact and engagement, establishing safety and comfort, stabilization (including best practices for medication use), practical assistance, connecting with social supports, information on coping, and connecting with relevant services. Dr. Katz also covers best practices for psychological first aid for children and adolescents, the five elements of mass trauma intervention, and a deeper look at the concept of resilience.