Cardiovascular disease remains a dominant global health burden, rooted in complex molecular and cellular pathobiology that evolves across an individual’s lifespan. Yet advances at the intersection of biomedical research and technology are revolutionizing how we understand, detect, and treat these complex conditions. Innovations in artificial intelligence, precision genomics, and advanced cardiac imaging now enable earlier, more accurate risk stratification, highly individualized therapeutic strategies, and deeper mechanistic insights, including the pivotal role of inflammation in atherogenesis and disease progression.
This special supplement, the seventh in the “Frontiers of Medical Research” series from the Icahn School of Medicine at Mount Sinai in collaboration with Science, showcases these breakthroughs, highlighting the molecular, computational, and clinical advances shaping the future of cardiovascular medicine.
Deepak L. Bhatt, MD, MPH, MBA, FACC, FAHA, FESC, MSCAI
Director of Mount Sinai Fuster Heart Hospital
Dr. Valentin Fuster Professor of Cardiovascular Medicine
Icahn School of Medicine at Mount Sinai
Filip Swirski, PhD
Director of the Cardiovascular Research Institute
Icahn School of Medicine at Mount Sinai