"The Genesis of Schizophrenia: An Origin Story” by Mount Sinai researcher Rebecca Birnbaum, MD, and Daniel Weinberger, MD, Director and CEO of the Lieber Institute for Brain Development (LIBD) on the Johns Hopkins medical campus, is featured on The American Journal of Psychiatry cover, highlighting the classic neurodevelopmental model of schizophrenia, from a current genetics perspective. Synthesizing emerging genomics insights, the authors suggest that rather than a focus on therapeutic intervention during adolescence or adulthood, prediction and prophylaxis in the pre/perinatal and neonatal stages may best comport with the biology of schizophrenia.