For the first time, stem cell-derived organoid models are allowing scientists to study the cellular development and intercellular interactions among microglia and other cell types within a 3D human brain microenvironment.
Lotje de Witte, MD, PhD, Assistant Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai, and her lab have become leading experts in the rapidly expanding field of cerebral organoids. Their work is adding to a body of knowledge about how the human immune system and its resident microglia contribute to neurodegenerative and neurodevelopmental disorders.