Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.
The Mount Sinai IBD group identified two distinct patterns of expression in the ileum of Crohn's disease patients. One of these patterns we then associated with anti-TNF non-response, highlighting a potential new set of biomarkers to help in therapy selection in Crohn's disease.
Dean of Translational Genetics, Director of the Charles Bronfman Institute for Personalized Medicine, Professor of Genetics and Genomic Sciences and Professor of Medicine (Gastroenterology)
Mount Sinai Health System